Endocrine / Hormonal
Gonadorelin
Gonadorelin is a synthetic decapeptide that mimics endogenous gonadotropin-releasing hormone to stimulate the pituitary release of gonadotropins.
Evidence: 0 articles
Goals: 0
Mechanism of Action
Gonadorelin binds to transmembrane GnRH receptors on pituitary gonadotrophic cells. In a pulsatile manner, this binding stimulates the synthesis and secretion of luteinizing hormone (LH) and, to a lesser extent, follicle-stimulating hormone (FSH). Conversely, continuous administration can lead to the desensitization of these receptors, resulting in a negative feedback effect on gonadotropin secretion.
Evidence Level
Review
0 studies published
Pharmacology
Molecular Weight
1182.3 Da