Endocrine / Hormonal
Histrelin
Histrelin is a potent synthetic GnRH analogue that functions as a long-acting inhibitor of gonadotropin secretion through pituitary receptor desensitization.
Evidence: 0 articles
Goals: 0
Mechanism of Action
Histrelin acts as a high-affinity agonist at the gonadotropin-releasing hormone (GnRH) receptor. While acute administration stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), continuous exposure—typically achieved via subcutaneous implantation—leads to the downregulation and desensitization of pituitary GnRH receptors, resulting in a profound and sustained suppression of gonadotropin secretion and subsequent reduction in sex steroid production.
Evidence Level
Review
0 studies published
Pharmacology
Molecular Weight
1323.5 Da