Sexual Health

Kisspeptin

Upstream regulator of GnRH neurons and the hypothalamic-pituitary-gonadal axis.

Evidence: 1 articles

Goals: 1

Mechanism of Action

Kisspeptin is a neuropeptide encoded by the KISS1 gene. It binds to the G protein-coupled receptor KISS1R (formerly GPR54). Kisspeptin neurons in the arcuate and anteroventral periventricular (AVPV) nuclei are the primary upstream regulators of gonadotropin-releasing hormone (GnRH) neurons. By stimulating GnRH release, kisspeptin drives the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary, making it a master regulator of reproductive endocrinology and pubertal onset.

Evidence Level

Clinical Trial - Human

1 study published

Studied For

Sexual Health & Libido

Bio-regulators modulating sexual function, libido, and reproductive signaling pathways.

Pharmacology

Molecular Weight

~1299 Da (Kisspeptin-10)

Half-Life

~30 seconds (kisspeptin-10, IV); minutes (subcutaneous)

Bioavailability

Low oral; SC and IV used in research