Endocrine / Hormonal
Leuprolide
Leuprolide is a synthetic peptide analogue of GnRH that functions as a potent inhibitor of gonadotropin secretion when administered continuously.
Evidence: 0 articles
Goals: 0
Mechanism of Action
Leuprolide acts as a GnRH receptor superagonist. Upon initial administration, it stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to a transient increase in gonadal steroids. However, continuous exposure results in the downregulation and desensitization of pituitary GnRH receptors, ultimately suppressing the secretion of LH and FSH and reducing serum testosterone or estrogen to castrate levels.
Evidence Level
Clinical Trial - Human
0 studies published
Pharmacology
Molecular Weight
1209.4 Da