Endocrine / Hormonal
Nafarelin
Nafarelin is a potent synthetic GnRH analog that induces pituitary desensitization to suppress gonadal steroidogenesis.
Evidence: 0 articles
Goals: 0
Mechanism of Action
Nafarelin acts as a potent agonist of the GnRH receptor. Initial administration triggers a transient surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH). However, continuous exposure leads to the down-regulation and desensitization of pituitary GnRH receptors, resulting in a sustained suppression of LH and FSH secretion and a subsequent decline in gonadal sex hormone production.
Evidence Level
Clinical Trial - Human
0 studies published
Pharmacology
Molecular Weight
1322.5 Da