Metabolic / Weight Management
Setmelanotide
Setmelanotide is a cyclic peptide analog that functions as a selective agonist of the melanocortin-4 receptor to regulate hunger and energy expenditure.
Evidence: 0 articles
Goals: 0
Mechanism of Action
Setmelanotide acts as a potent, selective agonist of the melanocortin-4 receptor (MC4R), a G-protein-coupled receptor located in the hypothalamus. By binding to and activating MC4R, it bypasses upstream genetic defects in the melanocortin pathway—such as POMC, PCSK1, or LEPR deficiencies—that otherwise impair satiety signaling, thereby helping to restore the regulation of hunger and energy expenditure.
Evidence Level
Clinical Trial - Human
0 studies published
Pharmacology
Molecular Weight
1117.3 Da