Stanozolol

Mechanism of Action

Stanozolol is a 17α-alkylated DHT derivative modified with a pyrazole ring (at A-ring), which enhances anabolic activity while reducing androgenic effects. The 17α-alkylation enables oral bioavailability by resisting hepatic first-pass metabolism. As a DHT derivative, stanozolol cannot aromatize to estrogen (no 3-keto group) and is not a substrate for 5α-reductase. It increases protein synthesis and nitrogen retention while exhibiting mild erythropoietic effects. Unlike testosterone esters, stanozolol does not cause water retention, making it studied for lean physique enhancement.

Evidence Level

Clinical Trial - Human

12 studies published