Endocrine / Hormonal
Triptorelin
Triptorelin is a potent GnRH agonist used to induce medical castration and suppress gonadotropin secretion through pituitary receptor desensitization.
Evidence: 0 articles
Goals: 0
Mechanism of Action
Triptorelin acts as a potent agonist of the gonadotropin-releasing hormone (GnRH) receptor. Upon initial administration, it causes a transient surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release. However, continuous exposure leads to the downregulation and desensitization of pituitary GnRH receptors, resulting in a profound and sustained suppression of LH and FSH secretion, which subsequently reduces sex steroid production to castrate levels.
Evidence Level
Clinical Trial - Human
0 studies published
Pharmacology
Molecular Weight
1311.4 Da