Dutasteride
Dual 5-alpha reductase inhibitor (types I and II)
Mechanism of Action
Dutasteride is a potent, dual inhibitor of both type I and type II 5-alpha-reductase enzymes. Unlike finasteride (type II selective), dutasteride reduces DHT levels by approximately 90-95% by blocking both isoforms. Type I 5AR is expressed in skin, brain, and liver, while type II is expressed in prostate and hair follicles. The broader inhibition profile results in more complete DHT suppression, studied for benign prostatic hyperplasia and androgenic alopecia in research contexts.
Evidence Chain
Dutasteride
COMPOUND
2 Research Goals
• Skin & Cosmetic
• Sexual Health & Libido
Evidence Strength
6 articles sourced
Knowledge Graph
(8 connections)Research Goals
(2)Research Evidence
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Related Compounds
Synergy & Compatibility
(5)Computational assessment of bio-regulatory compatibility with compounds sharing research goals. Scores reflect half-life alignment, receptor target overlap, and bioavailability data.
Highest Compatibility
Dutasteride + Finasteride
High Compatibility
Shared targets: 5-alpha-reductase type ii (srd5a2)
Computational assessment based on available pharmacology data. Does not account for individual variability, dose-dependent effects, or unstudied interactions. For research use only.
Community Observations
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For research use only. Not medical advice.