Finasteride
Type II 5-alpha reductase inhibitor; reduces DHT conversion
Mechanism of Action
Finasteride is a competitive inhibitor of type II 5-alpha-reductase (5AR), the enzyme that converts testosterone to dihydrotestosterone (DHT). By inhibiting 5AR type II (primarily expressed in prostate, hair follicles, and liver), finasteride reduces DHT levels by approximately 70%. Type I 5AR (expressed in skin and brain) is not significantly affected. Reduced DHT results in decreased androgenic stimulation of target tissues, studied for androgenic alopecia, benign prostatic hyperplasia, and as an adjunct during androgen administration to mitigate DHT-mediated side effects.
Evidence Chain
Finasteride
COMPOUND
2 Research Goals
• Skin & Cosmetic
• Sexual Health & Libido
Evidence Strength
6 articles sourced
Knowledge Graph
(8 connections)Research Goals
(2)Research Evidence
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Related Compounds
Synergy & Compatibility
(5)Computational assessment of bio-regulatory compatibility with compounds sharing research goals. Scores reflect half-life alignment, receptor target overlap, and bioavailability data.
Highest Compatibility
Finasteride + Dutasteride
High Compatibility
Shared targets: 5-alpha-reductase type ii (srd5a2)
Computational assessment based on available pharmacology data. Does not account for individual variability, dose-dependent effects, or unstudied interactions. For research use only.
Community Observations
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For research use only. Not medical advice.