Spironolactone
Aldosterone receptor antagonist with antiandrogenic properties
Mechanism of Action
Spironolactone is a competitive antagonist of the mineralocorticoid receptor (MR), opposing the action of aldosterone in the distal convoluted tubule. This promotes sodium excretion while sparing potassium, producing a diuretic effect without hypokalemia. Spironolactone also binds to androgen receptors (AR) as a weak antagonist and inhibits 17-alpha-hydroxylase and 17,20-desmolase, reducing androgen and testosterone synthesis. These antiandrogenic properties make it useful for androgenic alopecia, hirsutism, and hormone-sensitive conditions in research contexts.
Evidence Chain
Spironolactone
COMPOUND
1 Research Goal
• Skin & Cosmetic
Evidence Strength
6 articles sourced
Knowledge Graph
(7 connections)Research Evidence
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Trenbolone Acetate: Evidence-Based Research Review
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Related Compounds
Synergy & Compatibility
(5)Computational assessment of bio-regulatory compatibility with compounds sharing research goals. Scores reflect half-life alignment, receptor target overlap, and bioavailability data.
Highest Compatibility
Spironolactone + PT-141
Moderate Compatibility
Computational assessment based on available pharmacology data. Does not account for individual variability, dose-dependent effects, or unstudied interactions. For research use only.
Community Observations
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For research use only. Not medical advice.