Research Library

Structure Unavailable

Verified structure not on file

Sexual Health

Sildenafil

PDE5 inhibitor enhancing nitric oxide-mediated vasodilation in erectile tissue.

Mechanism of Action

Sildenafil is a small-molecule selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). During sexual stimulation, nitric oxide (NO) is released in the corpus cavernosum, activating guanylate cyclase to increase cGMP levels. Sildenafil prevents PDE5 from degrading cGMP, resulting in sustained smooth muscle relaxation and increased blood flow to erectile tissue. Unlike melanocortin agonists, sildenafil acts peripherally on the vascular system rather than centrally on arousal pathways.

Evidence Chain

Sildenafil

COMPOUND

1 Research Goal

• Sexual Health & Libido

Evidence Strength

Clinical Trial

1 article sourced

Knowledge Graph

(2 connections)

Compound (Center)

Research Goal

Linked Article

Research Goals

(1)

Sexual Health & Libido

Bio-regulators modulating sexual function, libido, and reproductive signaling pathways.

Research Evidence

(1)

PT-141 / Bremelanotide: Melanocortin Agonist for Hypoactive Sexual Desire Disorder — Regulatory and Clinical Evidence

PT-141, developed as bremelanotide, is a melanocortin receptor agonist FDA-approved (Vyleesi) for premenopausal women with hypoactive sexual desire disorder. This review summarizes the registrational clinical evidence.

Related Compounds

Oxytocin

Neuropeptide modulating social bonding, trust, and sexual arousal via oxytocin receptors.

PT-141 (Bremelanotide)

Melanocortin receptor agonist acting on CNS pathways to influence sexual arousal.

Kisspeptin

Upstream regulator of GnRH neurons and the hypothalamic-pituitary-gonadal axis.

Melanotan 2

Non-selective melanocortin receptor agonist studied for tanning and libido effects.

Synergy & Compatibility

(5)

Computational assessment of bio-regulatory compatibility with compounds sharing research goals. Scores reflect half-life alignment, receptor target overlap, and bioavailability data.

Highest Compatibility

Sildenafil + Testosterone Enanthate

High Compatibility

80%

Testosterone Enanthate

High Compatibility

Toremifene Citrate

Moderate Compatibility

Moderate Compatibility

Moderate Compatibility

Tamoxifen Citrate

Moderate Compatibility

View full comparison matrix

Computational assessment based on available pharmacology data. Does not account for individual variability, dose-dependent effects, or unstudied interactions. For research use only.

Community Observations

(0)

Qualitative, self-reported researcher observations. Distinct from peer-reviewed evidence — not medical advice.

No approved observations yet. Sign in to contribute.

Research Actions

Check Compatibility

Cross-reference this compound in the Stack Checker for synergies, antagonisms, and contraindications.

Build Protocol

Generate research-grade dosing frameworks by goal and experience level using the Protocol Builder.

View Clinical Studies

Search PubMed and ClinicalTrials.gov for published literature on this compound.

Research Use Only

For research use only. Not medical advice.

ARIA · Sign in to chat