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N-Acetyl Semax Amidate (7 aa)
Cognitive & Neurological

Adamax

N-Acetyl Semax Amidate — enhanced Semax derivative studied for cognitive enhancement and neuroplasticity.

Mechanism of Action

Bioregulator compound with targeted biochemical activity.

Evidence Chain

Adamax

COMPOUND

1 Research Goal

• Cognitive & Neurological

Evidence Strength

Clinical Trial

12 articles sourced

Knowledge Graph

(13 connections)
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Compound (Center)
Research Goal
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Research Evidence

(12)

Oxandrolone: Evidence-Based Research Review

6 min

Oxandrolone (17β-hydroxy-17α-methyl-2-oxa-5α-androstan-3-one) is a synthetic oral anabolic-androgenic steroid (AAS) derived from dihydrotestosterone (DHT). Characterized by a unique substitution of an oxygen atom for the carbon at the C-2 position in the A-ring, oxandrolone exhibits a high anabolic-

Clinical Trial

Nandrolone Decanoate: Evidence-Based Research Review

6 min

Nandrolone decanoate (ND) is a long-acting injectable ester of the anabolic-androgenic steroid (AAS) nandrolone (19-nortestosterone). Characterized by a high anabolic-to-androgenic ratio, ND has been utilized clinically for decades to treat conditions involving protein catabolism, bone density loss,

Clinical Trial

Testosterone Enanthate: Evidence-Based Research Review

6 min

Testosterone enanthate (TE) is a long-acting esterified formulation of the primary endogenous androgen, testosterone. Since its clinical introduction in the 1950s, it has served as a cornerstone for testosterone replacement therapy (TRT) in male hypogonadism and a reference compound in clinical rese

Clinical Trial

Stanozolol: Evidence-Based Research Review

5 min

Stanozolol is a synthetic anabolic-androgenic steroid (AAS) derived from dihydrotestosterone (DHT). Characterized by a high anabolic-to-androgenic ratio, it is clinically distinguished by its pyrazole ring modification and 17α-alkylation. Originally developed for the treatment of hereditary angioede

Clinical Trial

GLP-1 Receptor Agonism in Metabolic Signaling

8 min

Survey of GLP-1, GIP, and glucagon receptor research for metabolic signaling and incretin physiology.

Clinical Trial

BPC-157 and Tissue Repair Signaling Pathways

9 min

Comprehensive review of BPC-157 mechanisms in tissue repair, angiogenesis, and mucosal healing.

Clinical Trial

BDNF Upregulation and Synaptic Plasticity Research

8 min

Investigation of BDNF-promoting peptides and their mechanisms in neurotrophin signaling.

Clinical Trial

Melanocortin Receptor Agonists and Neuroendocrine Signaling

8 min

Examination of melanocortin receptor signaling and synthetic agonist research applications.

Clinical Trial

Testolone (RAD-140): Evidence-Based Research Review

5 min

Testolone (RAD-140) is a potent, non-steroidal selective androgen receptor modulator (SARM) originally developed by Radius Health, Inc. It was designed to overcome the limitations of conventional androgen therapy, such as prostate enlargement and virilization, by exhibiting high tissue selectivity.

Preclinical

Trenbolone Acetate: Evidence-Based Research Review

6 min

Trenbolone acetate (TBA) is a potent synthetic 19-nortestosterone derivative classified as an anabolic-androgenic steroid (AAS). Originally developed for veterinary applications—specifically to increase muscle mass and feed efficiency in beef cattle—TBA has become a focal point of pharmacological in

Preclinical

Pinealon (Glu-Asp-Pro): Peptide Bioregulation of Neural Gene Expression and Neuroprotection

5 min

Pinealon is a tripeptide (Glu-Asp-Pro) bioregulator investigated for neuroprotective and cognition-supporting effects. This review summarizes in vivo evidence from animal models.

Preclinical

Adalank and the Selank Peptide Class: Anxiolytic Peptide Pharmacology and Translational Rationale

6 min

Adalank is a synthetic analog of the anxiolytic peptide Selank incorporating an adamantane moiety. This review outlines the pharmacological rationale and preclinical evidence from the Selank peptide class that informs its development.

Preclinical

Overview

Adamax is a novel peptide compound representing an enhanced derivative of Semax — specifically, N-Acetyl Semax Amidate. This modification involves N-acetylation of the N-terminus and amidation of the C-terminus, structural changes designed to enhance stability against enzymatic degradation and extend the peptide's biological half-life. Adamax represents the next generation of ACTH-derived nootropic peptides, building on the established research foundation of Semax.

Mechanism of Action

Adamax shares Semax's core mechanisms, including upregulation of BDNF and NGF expression, modulation of dopaminergic and serotonergic systems, and neuroprotective effects against oxidative stress and excitotoxicity. The N-acetylation and C-terminal amidation modifications enhance resistance to aminopeptidases and carboxypeptidases, respectively, potentially extending the duration of action and improving bioavailability. The enhanced stability may allow for more sustained neurotrophic factor upregulation and prolonged cognitive effects compared to the parent compound.

Research Highlights

As a Semax derivative, Adamax is expected to share Semax's demonstrated benefits in cognitive enhancement, neuroprotection, and stroke recovery, with potentially enhanced pharmacokinetics. Research on Semax has established efficacy in improving memory, attention, and executive function, with neuroprotective effects in cerebral ischemia models. The modifications in Adamax are designed to enhance these properties. Direct clinical data on Adamax is limited compared to the extensive Semax literature, and much of the understanding is extrapolated from Semax research and structural analysis.

Dosage & Administration

As an investigational Semax derivative, Adamax has been explored via intranasal administration at doses similar to or lower than Semax, typically 100-300 mcg per day. No standardized dosing protocols exist. For research use only (RUO).

Safety Profile

Based on the established safety profile of Semax and the structural modifications, Adamax is expected to have a favorable safety profile. However, direct clinical safety data is limited. As an investigational peptide, full safety characterization is pending. Not approved by the FDA for any indication.

References

Asadulaeva ZM, et al. Semax in ischemic stroke. Zh Nevrol Psikhiatr. 2011. Kaplan AI, et al. Semax pharmacology. Bull Exp Biol Med. 1992. Structural analysis of N-acetylated peptide derivatives. All content is for educational and research purposes only.

FDA 2026 Regulatory Update

As of April–June 2026, this compound was among the 14 peptides formally removed from the FDA's Category 2 restricted compounding list following review by the Pharmacy Compounding Advisory Committee (PCAC). This regulatory shift permits licensed compounding pharmacies to produce and dispense this compound under appropriate oversight, subject to final 503A Bulks List adjudication expected following the July 23–24, 2026 PCAC meeting. This does not constitute FDA approval for therapeutic use. All information on this page is for research purposes only.

Synergy & Compatibility

(5)

Computational assessment of bio-regulatory compatibility with compounds sharing research goals. Scores reflect half-life alignment, receptor target overlap, and bioavailability data.

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Computational assessment based on available pharmacology data. Does not account for individual variability, dose-dependent effects, or unstudied interactions. For research use only.

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