Cognitive & Neurological
Synthetic ACTH fragments, heptapeptides, and angiotensin analogs studied for neurotrophin signaling, TREK-1 channel modulation, and synaptogenesis. Includes Selank, Semax, Dihexa, and related derivatives. Research into central nervous system signaling only — not for cognitive enhancement use.
15 Articles on This Research Goal
GLP-1 Receptor Agonism in Metabolic Signaling
Survey of GLP-1, GIP, and glucagon receptor research for metabolic signaling and incretin physiology.
BPC-157 and Tissue Repair Signaling Pathways
Comprehensive review of BPC-157 mechanisms in tissue repair, angiogenesis, and mucosal healing.
BDNF Upregulation and Synaptic Plasticity Research
Investigation of BDNF-promoting peptides and their mechanisms in neurotrophin signaling.
Melanocortin Receptor Agonists and Neuroendocrine Signaling
Examination of melanocortin receptor signaling and synthetic agonist research applications.
YK-11 vs RAD-140: Evidence-Based Comparison
Selective Androgen Receptor Modulators (SARMs) are a class of therapeutic compounds with similar anabolic properties to anabolic steroids but with reduced androgenic activity. This article compares YK-11 and RAD-140 (Testolone), two of the most potent compounds currently discussed in sports pharmaco
Ligandrol vs RAD-140: Evidence-Based Comparison
Selective Androgen Receptor Modulators (SARMs) were developed to provide the therapeutic benefits of androgen replacement therapy—such as increased muscle mass and bone density—while minimizing the adverse effects associated with conventional anabolic-androgenic steroids (AAS), specifically prostate
Ostarine vs RAD-140: Evidence-Based Comparison
Selective Androgen Receptor Modulators (SARMs) were developed to provide the anabolic benefits of traditional androgenic-anabolic steroids (AAS) while minimizing detrimental effects on the prostate, skin, and hair. Enobosarm (Ostarine) and Testolone (RAD-140) represent two of the most researched com
Testolone (RAD-140): Evidence-Based Research Review
Testolone (RAD-140) is a potent, non-steroidal selective androgen receptor modulator (SARM) originally developed by Radius Health, Inc. It was designed to overcome the limitations of conventional androgen therapy, such as prostate enlargement and virilization, by exhibiting high tissue selectivity.
Pinealon (Glu-Asp-Pro): Peptide Bioregulation of Neural Gene Expression and Neuroprotection
Pinealon is a tripeptide (Glu-Asp-Pro) bioregulator investigated for neuroprotective and cognition-supporting effects. This review summarizes in vivo evidence from animal models.
Adalank and the Selank Peptide Class: Anxiolytic Peptide Pharmacology and Translational Rationale
Adalank is a synthetic analog of the anxiolytic peptide Selank incorporating an adamantane moiety. This review outlines the pharmacological rationale and preclinical evidence from the Selank peptide class that informs its development.
Peptide Synergy: Cognitive Enhancement and Neuroprotection
Evidence-based review of cognitive peptide synergy, examining BDNF upregulation, neuroprotection, and synaptogenesis mechanisms.
Intranasal Peptide Delivery: Pharmacokinetic Foundations
A review of intranasal peptide delivery pharmacology, examining nasal cavity anatomy, absorption mechanisms, and bioavailability considerations.
Intranasal Bioavailability: Comparing Routes of Administration
A comparative review of peptide bioavailability across administration routes, with emphasis on intranasal delivery advantages and limitations.
Formulation Considerations for Intranasal Peptide Delivery
A technical review of formulation parameters affecting intranasal peptide stability, absorption, and tolerability.
Intranasal Peptide Stability and Storage Guidelines
A technical review of intranasal peptide stability, degradation pathways, and evidence-based storage guidelines.
9 Compounds Studied Under This Goal
Dihexa
Cognitive & NeurologicalAn angiotensin IV analog studied for synaptogenesis via the HGF/MET signaling pathway.
Read profile →PE-22-28
Cognitive & NeurologicalSpadin-derived peptide blocking TREK-1 channels. Studied for neuroplasticity and mood research.
Read profile →Semax
Cognitive & NeurologicalA synthetic ACTH fragment studied for neuroprotection and BDNF upregulation. Pharmaceutical approval in Russia for stroke recovery.
Read profile →Selank
Cognitive & NeurologicalA synthetic heptapeptide derived from tuftsin, studied for GABAergic system influence and BDNF expression.
Read profile →Adamax
Cognitive & NeurologicalN-Acetyl Semax Amidate — enhanced Semax derivative studied for cognitive enhancement and neuroplasticity.
Read profile →The Cognitive Stack
Blend StackNootropic peptide blend combining BDNF-upregulating and neuroprotective compounds.
Read profile →Adalank
Cognitive & NeurologicalAdamantane-modified anxiolytic peptide with enhanced membrane permeability and prolonged half-life
Read profile →Pinealon
Cognitive & NeurologicalPineal-derived tripeptide targeting CNS neuroprotection, cognition, and circadian regulation
Read profile →Testolone (RAD-140)
SARMsPotent non-steroidal SARM with neuroprotective properties
Read profile →All compounds, protocols, and content are for research use only (RUO). This knowledge graph documents biochemical research pathways and is not a treatment guide. For laboratory and research purposes only.