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SARMs

Testolone (RAD-140)

Potent non-steroidal SARM with neuroprotective properties

Mechanism of Action

Testolone (RAD-140) is a potent non-steroidal SARM with high affinity and selectivity for the androgen receptor. In preclinical models, RAD-140 demonstrates anabolic effects in skeletal muscle comparable to testosterone with significantly reduced androgenic activity in the prostate and seminal vesicles. Unique among SARMs, RAD-140 has shown neuroprotective effects in preclinical models of neurodegeneration, potentially via AR-mediated signaling in neurons. The compound does not aromatize and does not undergo 5-alpha reduction. Clinical development has explored applications in breast cancer (AR-positive) and muscle wasting conditions, though human clinical data remains limited.

Evidence Chain

Testolone (RAD-140)

COMPOUND

2 Research Goals

• Muscle & Tissue Growth

• Cognitive & Neurological

Evidence Strength

Clinical Trial

7 articles sourced

Knowledge Graph

(9 connections)
CompoundGoalGoalArticleArticleArticle
Compound (Center)
Research Goal
Linked Article

Research Evidence

(7)

Enobosarm (Ostarine / MK-2866): Evidence-Based Research Review

5 min

**Class:** SARM (Selective Androgen Receptor Modulator)

Clinical Trial

YK-11 vs RAD-140: Evidence-Based Comparison

6 min

Selective Androgen Receptor Modulators (SARMs) are a class of therapeutic compounds with similar anabolic properties to anabolic steroids but with reduced androgenic activity. This article compares YK-11 and RAD-140 (Testolone), two of the most potent compounds currently discussed in sports pharmaco

Peer-Reviewed

Ligandrol vs RAD-140: Evidence-Based Comparison

6 min

Selective Androgen Receptor Modulators (SARMs) were developed to provide the therapeutic benefits of androgen replacement therapy—such as increased muscle mass and bone density—while minimizing the adverse effects associated with conventional anabolic-androgenic steroids (AAS), specifically prostate

Peer-Reviewed

Ostarine vs RAD-140: Evidence-Based Comparison

6 min

Selective Androgen Receptor Modulators (SARMs) were developed to provide the anabolic benefits of traditional androgenic-anabolic steroids (AAS) while minimizing detrimental effects on the prostate, skin, and hair. Enobosarm (Ostarine) and Testolone (RAD-140) represent two of the most researched com

Peer-Reviewed

YK-11: Evidence-Based Research Review

5 min

YK-11 (17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester is a synthetic compound classified as a Selective Androgen Receptor Modulator (SARM). Unlike traditional non-steroidal SARMs such as Ostarine or Ligandrol, YK-11 possesses a steroidal

Peer-Reviewed

Testolone (RAD-140): Evidence-Based Research Review

5 min

Testolone (RAD-140) is a potent, non-steroidal selective androgen receptor modulator (SARM) originally developed by Radius Health, Inc. It was designed to overcome the limitations of conventional androgen therapy, such as prostate enlargement and virilization, by exhibiting high tissue selectivity.

Preclinical

Andarine (S-4): Evidence-Based Research Review

5 min

Andarine (also known as S-4 or GTx-007) is an early-generation, nonsteroidal selective androgen receptor modulator (SARM) belonging to the aryl propionamide class. Developed initially for the treatment of conditions such as muscle wasting and osteoporosis, Andarine demonstrates high affinity for the

Preclinical

Synergy & Compatibility

(5)

Computational assessment of bio-regulatory compatibility with compounds sharing research goals. Scores reflect half-life alignment, receptor target overlap, and bioavailability data.

Highest Compatibility

Testolone (RAD-140) + Andarine (S-4)

Moderate Compatibility

60%
View full comparison matrix

Computational assessment based on available pharmacology data. Does not account for individual variability, dose-dependent effects, or unstudied interactions. For research use only.

Community Observations

(0)

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